CBD & Bioavailability

CBD oils and lotions and vaping, oh my! Here’s why water-soluble CBD is your best bet at higher bioavailability.


Curious what the bioavailability of water-soluble CBD is versus its consumable counterparts? We’ll tell you.

We get it, the term ‘bioavailability’ sounds confusing. But, basically, it just refers to how much of a substance is absorbed into the bloodstream and then utilized in the body after we ingest or inhale it. Whether that substance is CBD or alcohol or a pain reliever like ibuprofen, typically, only a small percentage of it makes its way to our bloodstream. What doesn’t make it into the bloodstream is filtered out of our bodies naturally and therefore, the potential to reap the benefits of the desired substance is lost.

We know what you’re thinking. Lost?! That would be like ordering a pizza online and by the time it passes through the hostess, the kitchen, the server, and the pizza delivery guy, only one slice of the pie arrives at your doorstep. But that’s not what you paid for, you wanted to enjoy every morsel of that delicious pizza so; naturally, you’d want a refund.

You wouldn’t accept receiving less than the full amount you desired and expected, so why treat your CBD consumption any differently? If you want to reap the full spectrum of the widely proclaimed potential benefits, which includes reduced inflammation, decreased anxiety and stress, relieved muscle pain, and quicker recovery, then you want products by WillPower.

Here’s why.

Knowing how crucial the benefits and advantages of CBD are on our bodies, we made it our mission to use a form of consumption that would utilize as much of the versatile cannabinoid as humanly possible. We believe in supporting our customers on their quest to invest in the finest ingredients for their active bodies, and that’s why we chose a water-soluble form of CBD.

That being said, CBD is available in many forms. If you do some research you’ll learn that you’re able to consume the compound in a myriad of ways. Be that topically using lotions or creams, ingesting concentrates or tinctures sublingually (meaning, under your tongue), inhaling it by vaping, swallowing edibles and capsules, or using sprays – there are a lot of options out there.

At the end of the day, the form in which you prefer to consume CBD is your choice. But, what if we told you there are smarter ways to cater to your wellness goals? What if we told you, at the end of the day, not only can WillPower distribute a higher percentage of the cannabinoid into your system, WillPower’s products will also absorb into your bloodstream the quickest? This is because:

WillPower’s water-soluble CBD doesn’t have to go through your digestive system in order for your body to access its nutrients. Because our CBD is in a water-soluble form, our CBD can absorb into the interior lining of your stomach, directly reaching the bloodstream. This means your body gets to benefit from nearly 100% of the CBD. With other CBD brands having oil based extract, the oil must go through your bodies digestive system, leaving only a small fraction (typically 15-20%) of the nutrients your body can benefit from.

Think of our ReGenPCR protein powder as an IV, shooting nearly 100% of the valuable nutrients of CBD into your bloodstream. Thus, the question lies, how much gets absorbed when we rub it on our skin, put droplets under our tongue, or vape? We’ll break that down for you.


  • Water-Soluble vs. CBD Oil:

    Oil digestion takes hours in a healthy person. It’s estimated that nearly 94% of CBD oil is lost in the digestive process. We’ll spare you the scientific jargon and just explain that it first begins in your stomach, then it continues to your small intestines where its converted into fatty acids, which are then converted to carrier proteins, which are then released into the lymphatic system, and finally, those proteins are eventually dumped into the blood system.

    Verdict: Oil absorption rate is poor compared to a water-soluble.

  • Sublingual vs. Oral:

    Arguably, CBD oils consumed as tinctures, concentrates, lozenges, or sprays absorb quicker under the tongue than through oral consumption due to our tongue’s mucous membrane. Capillaries in the connective tissue diffuse the cannabinoid, which then allows it to enter the bloodstream. Bypassing your first-pass metabolism, the way oral consumption would otherwise require, increases the bioavailability.

    Verdict: Absorption rate is higher sublingually than orally.

  • Sublingual vs. Vaping:

    When inhaled, the CBD will enter your lungs before passing through tiny air sacs called alveoli before eventually moving directly into the bloodstream. Again, we see this method bypassing the first-pass metabolism, giving it a higher bioavailability than orally. And while there is little to no scientific evidence that vaping CBD is more potent or effective than ingesting it sublingually, there are notable pros and cons with both forms of consumption.Vaping is faster acting. If you need a quick fix, this may be your preferred method over oil droplets.
    However, the effects of sublingual oil drops last longer, even though they take longer to settle in. An online case study showed that while vaping may last anywhere from 3-5 hours, a high-quality tincture may last anywhere between 8 to 12 hours.

    Verdict: It really boils down to whether you’re more concerned with how quickly your body absorbs the CBD to begin reaping the benefits, or the duration of how long it lasts for.

Like we said, at the end of the day, the form in which you consume your CBD is your call. Here, at WillPower, we just prefer the quickest, most efficient method to reward our active bodies. We prefer water-soluble CBD and that’s why it’s the key ingredient in all our game-changing products.